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How is an IVF trial started and what are the successive steps of this treatment ?

From the practical point of view, IVF is a relatively demanding procedure. In short, this treatment consists of the following steps :
1. Preliminary investigations :
  • Hormonal screening of the woman;
  • UItrasound examination of the ovaries;
  • Hysterosalpingography (special IC-Ray of the uterus and the tubes);
  • Spermogram of the partner (quantitative microscopic examination of sperm).
2. Treatment :
  • Suppression of the natural secretion of certain hormones by a drug administered through nasal spray or intramuscular injection;
  • Regular blood and ultrasound assessment of ovarian activity, starting at day 5 of the menstrual cycle;
  • Retrieval of the oocytes;
  • Sperm collection and preparation (= capacitation);
  • In vitro insemination or injection of oocytes by treated sperm;
  • Incubation of eggs, allowing embryonic development;
  • Replacement of embryos in the womb.
3. Post hospitalization period :
  • "Luteal" supplementation: intramuscular injection of hormones aimed at favouring implantation of the embryo and at maintaining pregnancy;
  • Blood controls in order to diagnose pregnancy and to detect a possible hormonal deficiency.

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CHU Saint-Pierre, Université Libre de Bruxelles
UMC Sint-Pieter, Vrije Universiteit Brussel
Saint-Pierre University Hospital, Free University of Brussels